Additional file 1: Table S1. of Next-generation sequencing and FISH studies reveal the appearance of gene mutations and chromosomal abnormalities in hematopoietic progenitors in chronic lymphocytic leukemia

Clinico-biological characteristics from CLL patients. Table S2. Illumina Primer Design. Table S3. Validation of mutations detected at low frequency by ultra-deep NGS in flow-sorted cell fractions using 454 sequencing. Table S4. Patients’ characteristics regarding the presence of mutations in CD34+ progenitors. Table S5. Patients’ characteristics regarding the mutational burden maintenance or decrease in CD34+ progenitors. Table S6. Treatments prior bone marrow extraction of 4 CLL patients who relapsed and correlation with the CD19+ and CD34+ mutational status. Figure S1. Representation of the purity analysis of FACS sorted cell populations. Figure S2. Kaplan-Meier analysis of overall survival (A) and time to first therapy (B) in patients with mutations in their CD34+ progenitors. (DOCX 200 kb)