Back to Search Start Over

Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances

Authors :
Amna Hafeez
Zeeshan Khan
Muhammad Armaghan
Khushbukhat Khan
Eda Sönmez Gürer
Ahmad Faizal Abdull Razis
Babagana Modu
Zainab M. Almarhoon
William N. Setzer
Javad Sharifi-Rad
Source :
Frontiers in Molecular Biosciences. 10
Publication Year :
2023
Publisher :
Frontiers Media SA, 2023.

Abstract

Morusin is a natural product that has been isolated from the bark of Morus alba, a species of mulberry tree. It belongs to the flavonoid family of chemicals, which is abundantly present in the plant world and is recognized for its wide range of biological activities. Morusin has a number of biological characteristics, including anti-inflammatory, anti-microbial, neuro-protective, and antioxidant capabilities. Morusin has exhibited anti-tumor properties in many different forms of cancer, including breast, prostate, gastric, hepatocarcinoma, glioblastoma, and pancreatic cancer. Potential of morusin as an alternative treatment method for resistant malignancies needs to be explored in animal models in order to move toward clinical trials. In the recent years several novel findings regarding the therapeutic potential of morusin have been made. This aim of this review is to provide an overview of the present understanding of morusin’s beneficial effects on human health as well as provide a comprehensive and up-to-date discussion of morusin’s anti-cancer properties with a special focus on in vitro and in vivo studies. This review will aid future research on the creation of polyphenolic medicines in the prenylflavone family, for the management and treatment of cancers.

Details

ISSN :
2296889X
Volume :
10
Database :
OpenAIRE
Journal :
Frontiers in Molecular Biosciences
Accession number :
edsair.doi...........e0b600ce924c0e4ff1edcc00af0d211a
Full Text :
https://doi.org/10.3389/fmolb.2023.1168298