Vitamin D 3 supplementation at 50x the adequate intake attenuates disease pathophysiology in the spinal cord of male, but is toxic in female, G93A mouse model of amyotrophic lateral sclerosis (ALS)

Background: Vitamin D3 (D3) at 50x the adequate intake (AI) improves paw grip endurance in G93A mice. However, quadriceps apoptosis increases in females, indicating a threshold of toxicity. ALS is ...