Back to Search
Start Over
Evaluating a Targeted Bedside Measure of Cerebral Perfusion in a Nonhuman Primate Model of Neonatal Hypoxic-Ischemic Encephalopathy
- Source :
- Journal of Ultrasound in Medicine. 37:913-920
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Objectives To compare ultrasound-derived resistive indices (RIs) obtained at the level of the thalamus via fast Doppler ultrasound with traditional anterior cerebral artery measures in a model of neonatal hypoxic-ischemic encephalopathy and to correlate each with clinical outcomes. Methods Nine nonhuman primate neonates underwent no umbilical cord occlusion (n = 3), umbilical cord occlusion without hypothermia (n = 3), or umbilical cord occlusion with hypothermia (n = 3). The RI was measured in the anterior cerebral artery and thalamus on days 0, 1, and 4 of life. Magnetic resonance imaging with spectroscopy was performed on day 4. Results Mean thalamus and anterior cerebral artery RI values in the first 36 hours of life were statistically different in neonates who died (+0.13; P = .019) or developed cerebral palsy (−0.08; P = .003). Thalamic RI values showed stronger associations with serum and spectroscopic lactate values than those in the anterior cerebral artery. The umbilical cord occlusion-with-hypothermia group showed a significant increase in the RI in the thalamus but not the anterior cerebral artery. Conclusions Resistive index measurements in the thalamus may eventually supplement other bedside measures for predicting outcomes in the HIE population, but further studies need to differentiate the effect of hypothermia from illness severity on thalamic perfusion.
- Subjects :
- education.field_of_study
Radiological and Ultrasound Technology
business.industry
Thalamus
Population
Hypothermia
medicine.disease
Umbilical cord
Cerebral palsy
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
030225 pediatrics
medicine.artery
Anesthesia
medicine
Anterior cerebral artery
Radiology, Nuclear Medicine and imaging
Umbilical Cord Occlusion
medicine.symptom
Cerebral perfusion pressure
business
education
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 02784297
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Journal of Ultrasound in Medicine
- Accession number :
- edsair.doi...........e07d796a21dfa3462cef5f55537899a7