Back to Search Start Over

ChemInform Abstract: Novel and Highly Selective Postsynaptic α-Adrenoreceptor Antagonists: Synthesis and Structure-Activity Relationships of Alkane- Bridged (4-(Phenoxyethyl)-1-piperazinyl)-3(2H)-pyridazinones

ChemInform Abstract: Novel and Highly Selective Postsynaptic α-Adrenoreceptor Antagonists: Synthesis and Structure-Activity Relationships of Alkane- Bridged (4-(Phenoxyethyl)-1-piperazinyl)-3(2H)-pyridazinones

Authors :
R. Scapicchi
Gabriella Marucci
Giovannella Strappaghetti
F. Paparelli
Stefano Corsano
Source :
ChemInform. 26
Publication Year :
2010
Publisher :
Wiley, 2010.

Abstract

Summary The synthesis of selected 4-[4-(phenoxyethyl)-1-piperazinyl]-3(2 H )-pyridazinones and alkane-bridged dimers of 4-, 5- and 6-[4-(phenoxyethyl)-1-piperazinyl]-3(2 H )-pyridazinones is reported. The blocking activity of these compounds was determined on the pre- and postsynaptic α-adrenoreceptors of isolated rat vas deferons.

Details

ISSN :
09317597
Volume :
26
Database :
OpenAIRE
Journal :
ChemInform
Accession number :
edsair.doi...........e0437c30ad1b62c0b8ef2f47d08875b0
Full Text :
https://doi.org/10.1002/chin.199528179