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ChemInform Abstract: Novel and Highly Selective Postsynaptic α-Adrenoreceptor Antagonists: Synthesis and Structure-Activity Relationships of Alkane- Bridged (4-(Phenoxyethyl)-1-piperazinyl)-3(2H)-pyridazinones
ChemInform Abstract: Novel and Highly Selective Postsynaptic α-Adrenoreceptor Antagonists: Synthesis and Structure-Activity Relationships of Alkane- Bridged (4-(Phenoxyethyl)-1-piperazinyl)-3(2H)-pyridazinones
- Source :
- ChemInform. 26
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Summary The synthesis of selected 4-[4-(phenoxyethyl)-1-piperazinyl]-3(2 H )-pyridazinones and alkane-bridged dimers of 4-, 5- and 6-[4-(phenoxyethyl)-1-piperazinyl]-3(2 H )-pyridazinones is reported. The blocking activity of these compounds was determined on the pre- and postsynaptic α-adrenoreceptors of isolated rat vas deferons.
Details
- ISSN :
- 09317597
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........e0437c30ad1b62c0b8ef2f47d08875b0
- Full Text :
- https://doi.org/10.1002/chin.199528179