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Harvesting Potential Dissolution Advantages of Soluble Cocrystals by Depressing Precipitation Using the Common Coformer Effect
- Source :
- Crystal Growth & Design. 16:6719-6721
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- A highly soluble cocrystal of a poorly soluble drug has the potential to improve the dissolution rate and bioavailability. Reaping the potential dissolution advantage of soluble cocrystals is challenged by the precipitation of the parent drug during dissolution. Using the carbamazepine–nicotinamide cocrystal, we show that the use of excess coformer can be an effective strategy for eliminating precipitation during dissolution by taking advantage of the “common coformer effect”. When excess coformer is present, the solubility of the cocrystal is depressed, which leads to a lower degree of supersaturation. At an appropriate level, precipitation can be prevented and improved dissolution is realized.
- Subjects :
- Supersaturation
Precipitation (chemistry)
Chemistry
Nanotechnology
02 engineering and technology
General Chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
030226 pharmacology & pharmacy
Cocrystal
Bioavailability
03 medical and health sciences
0302 clinical medicine
Chemical engineering
General Materials Science
Solubility
0210 nano-technology
Dissolution
Lower degree
Subjects
Details
- ISSN :
- 15287505 and 15287483
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Crystal Growth & Design
- Accession number :
- edsair.doi...........e032f6df40017de2ce28bed13d833919