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Oxazole, thiazole, and imidazole derivatives of 2,6-di-tert-butylphenol as dual 5-lipoxygenase and cyclooxygenase inhibitors
- Source :
- Bioorganic & Medicinal Chemistry Letters. 3:1729-1734
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- Benzylidene di-tert-butylphenols containing oxazole, thiazole, and imidazole substituents are dual inhibitors of 5-lipoxygenase and cyclooxygenase with IC50 values
- Subjects :
- biology
Stereochemistry
Organic Chemistry
Clinical Biochemistry
Pharmaceutical Science
Biological activity
Biochemistry
Lipoxygenase
chemistry.chemical_compound
chemistry
Enzyme inhibitor
Drug Discovery
biology.protein
Molecular Medicine
Imidazole
Cyclooxygenase
Thiazole
Molecular Biology
Oxazole
2,6-Di-tert-butylphenol
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi...........df32ae923bcb89d5791e7fa052ade199
- Full Text :
- https://doi.org/10.1016/s0960-894x(00)80051-7