TOLNAFTATE LOADED LIPOSOMES- DESIGN, AND IN-VITRO EVALUATION

Objectives: Liposomes are colloidal particles formed as concentric bimolecular layers that are capable of encapsulating drugs. Liposomes have the potential for extending the duration of action for days or months. Tolnaftate is used as the topical antifungal agent. The purpose of this study was to provide the delivery of the topical drug at a sustained rate across intact skin to improve bioavailability. Methods: In present study, four different liposomes formulations of Tolnaftate were prepared by ethanol (solvent) injection method by varying the concentrations of phospholipids. The prepared liposomes were characterized for size, shape, entrapment efficiency, zeta potential, in-vitro drug release. Results: The % entrapment efficiency was found to be in the range of 90.24, 90.75, and 90.75%. The % entrapment efficiency of optimized batch LS4 was found to be 90.74 %. An in vitro drug release of about 82.114 % in 10 h was observed from optimum formulation of batch LS4. Conclusion: Based on different parameters like particle size, entrapment efficiency, drug release formulations of batch LS4 was selected as best formulation. Study concludes that Tolnaftate liposomes have potential for providing sustained delivery of drug. Peer Review History: Article received on- 15 November 2016, Revised on- 20 December, Accepted on- 3 January, Available online 15 January 2017 Academic Editor: Dr. Amany Mohamed Alboghdadly, Princess Nourah bint abdulrahman university, Riyadh, amalbgadley@pnu.edu.sa UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 4.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Dr. Mahmut Yildiztekin, Mugla Sitki Kocman University, Turkey, mahmutyildiztekin@mu.edu.tr Dr. Mohamed Derbali, Faculty of Pharmacy, Monastir, Tunisia, mohamed.edderbali@gmail.com Similar Articles: FORMULATION AND EVALUATION OF ELASTIC LIPOSOMES OF DECITABINE PREPARED BY ROTARY EVAPORATION METHOD This article has been cited by: Wang S, Dong Y, Meng X. Expression and clinical significance of SERPINA3 and EFEMP2 in endometrial carcinoma. European Journal of Inflammation. January 2018. Pubmed