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A Direct Aldol Addition of Simple Thioesters Employing Soft Enolization

Authors :
Don M. Coltart
Guoqiang Zhou
Julianne M. Yost
Source :
Synthesis. 2007:478-482
Publication Year :
2007
Publisher :
Georg Thieme Verlag KG, 2007.

Abstract

Simple thioesters undergo direct aldol addition to aldehydes in the presence of magnesium bromide-diethyl ether and N,N-diisopropylethylamine using untreated, reagent grade dichloromethane under atmospheric conditions. The reactions proceed extremely rapidly and in excellent yield.

Subjects

Subjects :
chemistry.chemical_classification
Chemistry
Magnesium
organic chemicals
Organic Chemistry
chemistry.chemical_element
Ether
Keto–enol tautomerism
Thioester
Catalysis
chemistry.chemical_compound
Aldol reaction
Reagent
Yield (chemistry)
Organic chemistry
Dichloromethane

Details

ISSN :
1437210X and 00397881
Volume :
2007
Database :
OpenAIRE
Journal :
Synthesis
Accession number :
edsair.doi...........de8647579270983210d5adfa9d948d4b

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