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Handcuffed antisense oligonucleotides for light-controlled cell-free expression

Authors :
Denis Hartmann
Michael J. Booth
Source :
Chemical Communications. 59:5685-5688
Publication Year :
2023
Publisher :
Royal Society of Chemistry (RSC), 2023.

Abstract

Topologically constraining antisense oligonucleotides (ASOs) into a handcuff structure, via photocages, silences their activity and opens up the possibility of precise light-controlled regulation of biological systems.

Subjects

Subjects :
Materials Chemistry
Metals and Alloys
Ceramics and Composites
General Chemistry
Catalysis
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials

Details

ISSN :
1364548X and 13597345
Volume :
59
Database :
OpenAIRE
Journal :
Chemical Communications
Accession number :
edsair.doi...........de71947013196f7311621dd9f4d2afeb

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