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Pumilanol, an antiprotozoal isoflavanol from Tephrosia pumila
- Source :
- Phytochemistry Letters. 1:175-178
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- A novel isoflavan-4-ol (pumilanol), ( re l)-3β-(2′-hydroxy-4′,5′-methylenedioxyphenyl)-6-methoxy-4α,7-dihydroxybenzo-3,4-dihydropyran ( 1 ) and two known flavonoids, tephrinone ( 2 ) and rotenone ( 3 ) together with lupeol and stigmasterol were isolated from the roots of Tephrosia pumila (Fabaceae) from a collection made in Andhra Pradesh, India. The structures of the compounds were determined by MS, 1D and 2D-NMR spectral analysis. Pumilanol ( 1 ) exhibited significant antiprotozoal activity against T. b. rhodensiense , T. cruzi and L. donovani with IC 50 of 3.7, 3.35 and 17.2 μg/mL, respectively, but displayed high toxicity towards L-6 (IC 50 of 17.12 μg/mL) rat skeletal myoblasts.
Details
- ISSN :
- 18743900
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Phytochemistry Letters
- Accession number :
- edsair.doi...........de58b98d096d3fb45ef1b798c256b221