PS1 - 2. Involvement of the hypothalamic Orexin system in Olanzapine induced metabolic side-effects

It has been shown that peripheral injections of Olan induce Fos activation in neurons of the lateral hypothalamus/ perifornical area and that a large part of these activated neurons are Orexin A-positive (Stephanidis et al., 2009). In ongoing experiments we aim to confirm the involvement of the central Orexin system in the metabolic side-effects of Olan by comparing the hyperglycemic effects of IG Olan infusions between animals treated ICV with an Orexin A antagonist or Vehicle.