Über eine selektive Mitosehemmung und -schädigung bei jungen Ratten durch Synthalin A

A single subcutaneous injection of synthalin-A does not affect the cytoplasma ofA-cells in pancreatic islets of the rat during the 1st–5th day of life, in contrast to adult animals. Selective action was found on mitoticA-cells: reduction of mitotic frequency to 25% of the normal rate, and pathological mitoses in the sense of the so-called primary effect. The mitoses ofB-cells, exocrine pancreatic cells and intestinal epithelia seemed to be unchanged, although the mitotic rate was higher than inA-cells.