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Evolution of rhodium(III) and iridium(III) chelates as metallonucleases
- Source :
- Polyhedron. 110:73-84
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Half sandwich cationic mononuclear rhodium(III) and iridium(III) complexes [(η5-C5Me5)M(L)Cl]Cl·2H2O where L = dipyridylamine (dpa) (M = Rh, 1 and Ir, 2) and dipyridylketone (dpk) (M = Rh, 3 and Ir, 4) have been synthesized and characterized. The structure of a representative complex (1) was authenticated by single crystal X-ray diffraction analysis. Complexes 1–4 have been fully characterized by various physicochemical techniques, namely elemental analysis, spectral (IR, 1H, NMR, UV–Vis), electrochemical studies (cyclic voltammetry (CV) and differential pulse voltammetry (DPV)). Notably, the UV absorption spectral titrations of the synthesized complexes with DNA reveal that the complexes bind to calf thymus DNA (CT-DNA) through the intercalation mode. The DNA solution hydrodynamic volume (viscosity) measurements show that the interaction of the compounds with CT-DNA occurs by classical intercalation. A molecular docking study suggested intercalation between the synthesized compounds and nucleotide base pairs. Cyclic voltammetry studies of the complexes indicate irreversible oxidation and reduction potentials. A gel electrophoresis assay demonstrates the ability of the complexes to cleave pUC19 DNA. The antibacterial activities were assayed against selected Gram(−ve) and Gram(+ve) microorganisms. The cytotoxic properties of the metal complexes have been evaluated using a brine shrimp lethality bioassay. The results suggest that the binding affinity of 1–4 lies in the order 1 > 4 > 2 > 3.
- Subjects :
- Gel electrophoresis
010405 organic chemistry
Stereochemistry
Intercalation (chemistry)
chemistry.chemical_element
010402 general chemistry
01 natural sciences
0104 chemical sciences
Rhodium
Inorganic Chemistry
Metal
chemistry
visual_art
Materials Chemistry
visual_art.visual_art_medium
Titration
Iridium
Differential pulse voltammetry
Physical and Theoretical Chemistry
Cyclic voltammetry
Nuclear chemistry
Subjects
Details
- ISSN :
- 02775387
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Polyhedron
- Accession number :
- edsair.doi...........dd775beee155fde6226ec405b29886a6