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Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat1
- Source :
- Transplantation. 75:1881-1887
- Publication Year :
- 2003
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2003.
-
Abstract
- Background The effects of tacrolimus (FK506) and malononitrilamides (MNA) (FK778 and FK779) monotherapy and combination therapy were examined in prevention of acute heart and kidney allograft rejection and reversal of ongoing acute heart allograft rejection in the rat. Methods. Brown Norway (RT1 n )-to-Lewis (RT1 1 ) and ACI (RT1 a )-to-Lewis (RT1 1 ) combinations were used, respectively, for heart and kidney transplantation models. Immunosuppressants were administered orally from day 1 to day 14 for preventing acute rejection and from day 4 to day 34 after transplantation for the reversal of ongoing acute rejection. Results. In the prevention of acute heart rejection model, recipient rats treated with monotherapy of tacrolimus or MNA (FK778, FK779) showed a dose-related prolongation of mean survival time (MST) compared with naive control rats (P
- Subjects :
- Transplantation
Kidney
Chemotherapy
medicine.medical_specialty
Combination therapy
business.industry
medicine.medical_treatment
Urology
chemical and pharmacologic phenomena
medicine.disease
Tacrolimus
Surgery
Calcineurin
surgical procedures, operative
medicine.anatomical_structure
Medicine
business
Kidney transplantation
Heart allograft
Subjects
Details
- ISSN :
- 00411337
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Transplantation
- Accession number :
- edsair.doi...........dd486c0a42be9565b5269b2efd0ec190