BNCT of Malignant Melanoma-Radiobiological Analysis and Data Comparison with Conventional Radiotherapy

Research on selective melanoma neutron capture therapy was initiated by Y. Mishima and his associates, consisting of physicists, chemists, pharmacologists, radiobiologists, and medical scientists. Following basic research of 13 years, this team started the first clinical. trial of melanoma BNCT using10B-paraboronophenylalanine (BPA) in 1987 and have treated 16 patients with various types of melanoma1−4.