Nanophotonic Functional Imaging and Related Nanotoxicity Issues

Early detection of the micrometastases is still a challenge. Here, we demonstrate the use of nanoprobes engineered from the single-domain antibodies and fluorescent quantum dots for single- and two-photon detection and imaging of human micrometastases in ex vivo biological samples of breast and pancreatic metastatic tumour models and analyze the nanotoxicity issues related to their potential in vivo applications.