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Cyclisation of histidine containing peptides in the solid-phase by anchoring the imidazole ring to trityl resins
- Source :
- Tetrahedron Letters. 40:809-812
- Publication Year :
- 1999
- Publisher :
- Elsevier BV, 1999.
-
Abstract
- Head-to-tail histidine containing cyclopeptides can be efficiently synthesised by a three-dimensional orthogonal solid-phase strategy (Fmoc/tBu/allyl) via anchoring the imidazole ring to trityl-resins. Furthermore, Fmoc-His(Trt-®-OA1 can be a useful starting support for the preparation of diketopiperazine combinatorial libraries.
Details
- ISSN :
- 00404039
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........dc766bc416135fee979657d3f665c364