1442-P: Incidence and Risk Factors for Type 2 Diabetes among the Offspring of Long-Lived Individuals: The Long Life Family Study

Centenarians and their offspring appear to have a reduced risk of type 2 diabetes (T2D) compared to similarly aged controls. We determined the incidence of and potential risk factors for T2D among the offspring of probands and their spouses (mean age =60 years; SD=8 years), in the Long Life Family Study (LLFS), a multicenter cohort study of two-generation families with a clustering of healthy aging and exceptional survival. Incident T2D was defined as fasting serum glucose ≥126 mg/dl, or HbA1c of ≥6.5%, or self-reported with doctor diagnosis of T2D, or the use of antidiabetic medication during a mean follow-up 7.9 ± 1.1 years. Among nondiabetic offspring (n=1585) and spouses (n=495) at study entry, 58 (3.7%) and 19 (3.8%) developed incident T2D, respectively. By comparison, 5.1% of comparable aged nondiabetics developed T2D in the Framingham Offspring Study. At Visit 1, BMI, waist circumference, and fasting serum triglycerides were positively, whereas HDL-C and adiponectin were inversely associated with incident T2D among offspring in LLFS (all P Disclosure I. Miljkovic: None. R. Cvejkus: None. P. An: None. B. Thyagarajan: None. R. Boudreau: None. J.M. Zmuda: None. Funding National Institute on Aging