Back to Search Start Over

Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: cohort study in OpenSAFELY using linked primary care, secondary care and death registration data

Authors :
Frank Hester
Christopher T Rentsch
Alex J Walker
Helen J Curtis
Peter Inglesby
Laurie A. Tomlinson
Elizabeth A. Williamson
Sam Harper
Ben Goldacre
Caroline E Morton
Amir Mehrkar
John Parry
Wong Ay
Anna Schultze
William J Hulme
Seb Bacon
Rosalind M Eggo
Charlotte Warren-Gash
Krishnan Bhaskaran
Rohini Mathur
Brian MacKenna
Liam Smeeth
V Mahalingasivam
Daniel Grint
David M. Evans
Chris Bates
Evans Sjw.
Kevin Wing
George Hickman
Ian J. Douglas
Helen Mcdonald
Jonathan Cockburn
Publication Year :
2021
Publisher :
Cold Spring Harbor Laboratory, 2021.

Abstract

BackgroundThere is concern about medium to long-term adverse outcomes following acute COVID-19, but little relevant evidence exists. We aimed to investigate whether risks of hospital admission and death, overall and by specific cause, are raised following discharge from a COVID-19 hospitalisation.Methods and FindingsWorking on behalf of NHS-England, we used linked primary care and hospital data in OpenSAFELY to compare risks of hospital admission and death, overall and by specific cause, between people discharged from COVID-19 hospitalisation (February-December 2020), and (i) demographically-matched controls from the 2019 general population; (ii) people discharged from influenza hospitalisation in 2017-19. We used Cox regression adjusted for personal and clinical characteristics.24,673 post-discharge COVID-19 patients, 123,362 general population controls, and 16,058 influenza controls were followed for ≤315 days. Overall risk of hospitalisation or death (30968 events) was higher in the COVID-19 group than general population controls (adjusted-HR 2.23, 2.14-2.31) but similar to the influenza group (adjusted-HR 0.94, 0.91-0.98). All-cause mortality (7439 events) was highest in the COVID-19 group (adjusted-HR 4.97, 4.58-5.40 vs general population controls and 1.73, 1.60-1.87 vs influenza controls). Risks for cause-specific outcomes were higher in COVID-19 survivors than general population controls, and largely comparable between COVID-19 and influenza patients. However, COVID-19 patients were more likely than influenza patients to be readmitted/die due to their initial infection/other lower respiratory tract infection (adjusted-HR 1.37, 1.22-1.54), and to experience mental health or cognitive-related admission/death (adjusted-HR 1.36, 1.01-2.83); in particular, COVID-19 survivors with pre-existing dementia had higher risk of dementia death. One limitation of our study is that reasons for hospitalisation/death may have been misclassified in some cases due to inconsistent use of codes.ConclusionsPeople discharged from a COVID-19 hospital admission had markedly higher risks for rehospitalisation and death than the general population, suggesting a substantial extra burden on healthcare. Most risks were similar to those observed after influenza hospitalisations; but COVID-19 patients had higher risks of all-cause mortality, readmissions/death due to the initial infection, and dementia death, highlighting the importance of post-discharge monitoring.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........dc5357932f986d95d6f068c9dd3d4d82
Full Text :
https://doi.org/10.1101/2021.07.16.21260628