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Cholesteryl Ester Transfer Protein and Lipid Metabolism and Cardiovascular Diseases
- Source :
- Advances in Experimental Medicine and Biology ISBN: 9789811560811
- Publication Year :
- 2020
- Publisher :
- Springer Singapore, 2020.
-
Abstract
- In this chapter, we present the major advances in CETP research since the detection, isolation, and characterization of its activity in the plasma of humans and several species. Since CETP is a major modulator of HDL plasma levels, the clinical importance of CETP activity was recognized very early. We describe the participation of CETP in reverse cholesterol transport, conflicting results in animal and human genetic studies, possible new functions of CETP, and the results of the main clinical trials on CETP inhibition. Despite major setbacks in clinical trials, the hypothesis that CETP inhibitors are anti-atherogenic in humans is still being tested.
- Subjects :
- 2019-20 coronavirus outbreak
biology
business.industry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Reverse cholesterol transport
Lipid metabolism
Plasma levels
Cetp inhibition
Pharmacology
carbohydrates (lipids)
03 medical and health sciences
0302 clinical medicine
Cholesterylester transfer protein
biology.protein
Medicine
lipids (amino acids, peptides, and proteins)
Lipoprotein metabolism
030212 general & internal medicine
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Advances in Experimental Medicine and Biology ISBN: 9789811560811
- Accession number :
- edsair.doi...........dc343e429b9ee5e48d5d995784523373