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Protection from DNA Damage by Use of an Aronia Food Supplement—Results from a Pilot Human Intervention Study
- Source :
- Current Pharmacology Reports. 5:188-195
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Polyphenols from fruits and other plant sources exhibit protective effects against DNA damage and markers of oxidative stress. Meanwhile, previous investigations tested rather large volumes of polyphenol-rich fruit juices; hence, there is a lack of information on the efficacy of small-volume supplementation concepts suitable for daily routine. We designed a 6-week pilot study on the use of such a food supplement (aronia+) including ten healthy male volunteers and tested for effects on DNA integrity, oxidation-related parameters (Nrf2, SOD, GPx, CAT, and oxidized LDL), and blood lipids. Tendencies towards a decrease were observed for both total and background DNA strand breaks but were not significant after 4-week consumption of the food supplement. Transcription levels of Nrf2 were elevated; meanwhile, Nrf2/ARE-related enzymes were not affected (GPx) or even slightly decreased (SOD, CAT). Marginal reduction was observed for total and LDL cholesterol, whereas other parameters remained almost unchanged. This explorative study yields first indications on protective effects on DNA damage after intake of even small volumes of polyphenol-rich food supplements. These observations must be confirmed in a follow-up study with a higher number of included volunteers and an integration of a control group in order to clearly assess the effect of the intervention.
- Subjects :
- 0301 basic medicine
Pharmacology
chemistry.chemical_classification
business.industry
DNA damage
Blood lipids
medicine.disease_cause
Biochemistry
Intervention studies
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Enzyme
Food supplement
chemistry
Polyphenol
030220 oncology & carcinogenesis
Drug Discovery
Genetics
Medicine
Aronia
Food science
business
Oxidative stress
Subjects
Details
- ISSN :
- 2198641X
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Current Pharmacology Reports
- Accession number :
- edsair.doi...........dc1e8717f87f463c7c1cbf07c635cdf4