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A phenanthroindolizidine glycoside with HIF-1 inhibitory activity from Tylophora atrofolliculata
- Source :
- Phytochemistry Letters. 31:39-42
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- A phenanthroindolizidine glycoside 6-O-β-D-glucopyranosyl-tylophorinidine (1), the first glycoside of phenanthroindolizidine alkaloid in nature, was isolated from whole plants of Tylophora atrofolliculata (Asclepiadaceae). Its structure was elucidated by means of spectral and chemical evidences. Compound 1 showed potent inhibitory effect (IC50: 69 ± 13 nM) on hypoxia induced factor-1 (HIF-1) activation. It was discovered that glucosylation at C-6 of 1 could lead to reduction in cytotoxicity against normal cells and enhance its selectivity in tumor cells inhibition.
- Subjects :
- chemistry.chemical_classification
biology
010405 organic chemistry
Chemistry
Alkaloid
Glycoside
Tumor cells
Plant Science
Inhibitory postsynaptic potential
Tylophora
biology.organism_classification
01 natural sciences
Biochemistry
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Cytotoxicity
Agronomy and Crop Science
Inhibitory effect
IC50
Biotechnology
Subjects
Details
- ISSN :
- 18743900
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Phytochemistry Letters
- Accession number :
- edsair.doi...........dc1d75d47fd39146d2516bda47fed380