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Mitochondria-targeted porphyrin-based photosensitizers containing triphenylphosphonium cations showing efficient in vitro photodynamic therapy effects
- Source :
- Journal of Porphyrins and Phthalocyanines. 23:1505-1514
- Publication Year :
- 2019
- Publisher :
- World Scientific Pub Co Pte Lt, 2019.
-
Abstract
- Subcellular organelle-targeted photosensitizers have recently reported to be effective photodynamic therapy (PDT) agents. In this work, three porphyrin-derived photosensitizers, containing one, two or four triphenylphosphonium targeting groups, were synthesized and characterized by NMR, HRMS, UV-vis and fluorescence spectroscopy. These photosensitizers showed similar photophysical properties to classical porphyrins and exhibited excellent [Formula: see text]O[Formula: see text] quantum yields in acetonitrile. Subcellular colocalization indicated that all three photosensitizers specifically stain the mitochondria of HeLa cells. Photosensitizer mito-dp, containing two triphenylphosphonium cations was found to be the most uptaken by cells and exhibited the best PDT effect with an effective phototoxicity (IC[Formula: see text] (light) [Formula: see text] 12.4 nM), suggestive of a higher practicable potential of mitochondria-targeted PDT agents in cancer therapy.
Details
- ISSN :
- 10991409 and 10884246
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Journal of Porphyrins and Phthalocyanines
- Accession number :
- edsair.doi...........dbf264cb51fb336a57aeb3fdf315f121