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Sulfonium salts as derivatizing agents
- Source :
- Journal of Chromatography B: Biomedical Sciences and Applications. 494:109-117
- Publication Year :
- 1989
- Publisher :
- Elsevier BV, 1989.
-
Abstract
- An automated gas chromatographic method for determination of theophylline in plasma is described. A novel feature of this assay is the use of triethylsulfonium hydroxide as an on-column alkylating agent. A simple extraction procedure together with automated sample injection and data processing has facilitated processing of large numbers of samples generated in pharmacokinetic studies. The between-run coefficient of variation was 2.2% at 5 micrograms/ml (n = 5) and 3.9% at 15 micrograms/ml (n = 6). Within-run coefficient of variation was 2.4% at 5 micrograms/ml (n = 9) and 3.3% at 15 micrograms/ml (n = 6). Accuracy was 105% at a concentration of 5 micrograms/ml and 102% at 15 micrograms/ml.
Details
- ISSN :
- 03784347
- Volume :
- 494
- Database :
- OpenAIRE
- Journal :
- Journal of Chromatography B: Biomedical Sciences and Applications
- Accession number :
- edsair.doi...........dbeb475b1797d805a792fba0ed8ace37