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A one-step base-free synthesis of N-arylamides via modified pivaloyl mixed anhydride mediated amide coupling

Authors :
Fenghua Mao
Can Jin
Jie Wang
Hui Yang
Xinhuan Yan
Xiaoqing Li
Xiangsheng Xu
Source :
Organic & Biomolecular Chemistry. 21:3825-3828
Publication Year :
2023
Publisher :
Royal Society of Chemistry (RSC), 2023.

Abstract

Pivalic anhydride is shown to be an effective reagent for direct amidation of carboxylic acids with N-alkyl anilines under base-free conditions.

Details

ISSN :
14770539 and 14770520
Volume :
21
Database :
OpenAIRE
Journal :
Organic & Biomolecular Chemistry
Accession number :
edsair.doi...........dbb56c2dec83591e3f7256de16e2e07f