A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis

Authors :: Blandine Rammaert
Pierre-Yves Bochud
Anne-Sophie Brunel
Agnieszka Wojtowicz
Sophie Candon
Maria Pilar Gallego Hernanz
Olivier Lortholary
Source :: Open Forum Infectious Diseases. 10
Publication Year :: 2023
Publisher :: Oxford University Press (OUP), 2023.
Abstract: We investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and a prospective matched-control study. We found that an SNP located in interleukin-1B at rs1143627 was significantly associated with the risk of developing IRIS-CDC.

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