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Research of the Plasma Protein Profile in Comparison with the Biochemical Parameters of Blood of Volunteers in a 21-Day Head Down Bed Rest
- Source :
- Human Physiology. 46:423-431
- Publication Year :
- 2020
- Publisher :
- Pleiades Publishing Ltd, 2020.
-
Abstract
- Study of changes in the proteome of extracellular body fluids under conditions of simulated weightlessness of medium duration (21 days) remains relevant for clarifying the physiological mechanisms of homeostasis regulation and is important for gravitational physiology and medicine. Plasma samples of 8 healthy volunteers participating in head down bed rest (HDBR –6°) experiment were studied using semi-quantitative proteomics methods. Each volunteer participated both in the control session and in the session with physical training for negative changes prevention. By the end of HDBR, significant changes in the concentration of proteins involved in platelet degranulation, blood coagulation, fibrinolysis, proteolysis regulation, complement activation, and the immune response were detected in both sessions. The following changes in biochemical parameters of carbohydrate metabolism and regulation of circulating blood volume were shown: a significant increase in renin concentration and a tendency to an increase in aldosterone; an increase in fasting insulin concentration and a tendency to an increase in the insulin resistance index. Physical training did not have a significant effect on biochemical parameters, except for the representation of cholesterol fractions, un which a significant decrease in the concentration of high-density lipoprotein cholesterol observed in HDBR became statistically insignificant in session with physical training. However, the protein composition in blood plasma of volunteers in the prophylaxis session changed less compared to HDBR. Physical training resulted in increase in the concentration of proteins involved in the normalization of carbohydrate and lipid metabolism, such as a macrophage stimulating protein and phosphatidylinositol-glycan-specific phospholipase D, which indicates the effectiveness of preventive measures.
- Subjects :
- medicine.medical_specialty
Aldosterone
Physiology
business.industry
05 social sciences
Blood volume
Carbohydrate metabolism
medicine.disease
Blood proteins
050105 experimental psychology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Insulin resistance
Platelet degranulation
chemistry
Physiology (medical)
Internal medicine
Renin–angiotensin system
Blood plasma
medicine
0501 psychology and cognitive sciences
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 16083164 and 03621197
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Human Physiology
- Accession number :
- edsair.doi...........db32f286703a7e7caab071ac743f1cff