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A new class of leukotriene biosynthesis inhibitors: The discovery of MK0591
- Source :
- Bioorganic & Medicinal Chemistry Letters. 2:1395-1398
- Publication Year :
- 1992
- Publisher :
- Elsevier BV, 1992.
-
Abstract
- The evolution of a quinoline based FLAP inhibitor, L-674,636, into a novel quinoline-indole hybrid compound: MK0591, is described. The new series of compounds are more potent, particularly in binding to FLAP, in inhibiting LTB4 biosynthesis in stimulated human PMN, and in the human whole blood assay.
Details
- ISSN :
- 0960894X
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi...........db15c742241882af2880740eb3ca84c6
- Full Text :
- https://doi.org/10.1016/s0960-894x(00)80520-x