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Adsorptive stripping voltammetric determination of fluoroquinolones in pharmaceuticals
- Source :
- Journal of Food and Drug Analysis. 13
- Publication Year :
- 2020
- Publisher :
- The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA), 2020.
-
Abstract
- Sensitive cathodic stripping voltammetric methods have been developed for two fluoroquinolone antibacterial drugs, norfloxacin and enoxacin. Dimethylformamide (DMF) and 0.1 M hydrochloric acid were used as media for norfloxacin and enoxacin respectively. Potassium chloride was used as base electrolyte. A reduction wave was observed for norfloxacin within the range of -1.02 to -1.13V and for enoxacin within -0.93 to -1.07V. Linear calibration ranges for norfloxacin and enoxacin were observed within 20-100μg/mL and 1-40μg/mL with detection limits of 10μg/mL and 50ng/mL respectively Relative standard deviations (RSD) for the analysis of 10μg/mL norfloxacin and 10μg/mL enoxacin (n=5) were observed 1.l% and 0.2%. The presence of glucose, lactose, sorbitol, gum arabic, starch, magnesium stearate, methylparaben and propylparaben did not affect the determination. The methods were used for the analysis of pharmaceutical preparations and quantitative recoveries were obtained with relative deviation within 1.6-4.75%.
- Subjects :
- Pharmacology
Detection limit
0303 health sciences
Chromatography
Methylparaben
030309 nutrition & dietetics
010401 analytical chemistry
Hydrochloric acid
01 natural sciences
0104 chemical sciences
03 medical and health sciences
chemistry.chemical_compound
chemistry
medicine
Enoxacin
Dimethylformamide
Magnesium stearate
Norfloxacin
Propylparaben
Food Science
medicine.drug
Subjects
Details
- ISSN :
- 22246614
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of Food and Drug Analysis
- Accession number :
- edsair.doi...........db0b1be03f0ea5be2e0aa294d6a2059d