Back to Search
Start Over
Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs
- Source :
- Polymer Chemistry. 4:2958
- Publication Year :
- 2013
- Publisher :
- Royal Society of Chemistry (RSC), 2013.
-
Abstract
- Pluronic copolymer L61 was found to possess a stealth function for liposomal drug delivery, comparing favorably to PEG. The liposomes modified with 0.1% L61 (w/w) were long-circulating, and preferentially accumulated in the tumor site. The paclitaxel-loaded L61-liposomes with a single injection dose could successfully arrest the tumor growth, lasting for five days, and displayed better treatment outcomes compared to the non-modified liposomes and even the PEGylated liposomes.
Details
- ISSN :
- 17599962 and 17599954
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Polymer Chemistry
- Accession number :
- edsair.doi...........db067b61b2237ecabfcb2833e467d4a2