Food Protein–Induced Enterocolitis Syndrome Food Challenges: Experience From a Large Referral Center

KY Wang, J Lee, A Cianferoni. J Allergy Clin Immunol Pract. 2019;7(2):444–450 To describe experience with oral food challenges (OFCs) for food protein-induced enterocolitis syndrome (FPIES), using a protocol that includes ingestion of one-third of the goal food serving size with 4 hours of observation, followed by home titration to goal dose. A total of 119 subjects underwent 169 OFCs at Children’s Hospital of Philadelphia to 19 different foods between 2014 and 2017. Patients with food protein-induced allergic proctocolitis were excluded. Patients with intermittent food exposures and delayed emesis within 1 to 4 hours and/or diarrhea within 5 to 10 hours were classified …