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Primary Structure of a Ribonuclease from Bovine Brain1

Authors :
Katoh H
Ishii M
Komoda Y
Kazuko Ohgi
Yoshio Takizawa
Masachika Irie
Akihiro Sanda
Hideaki Watanabe
Source :
The Journal of Biochemistry. 104:939-945
Publication Year :
1988
Publisher :
Oxford University Press (OUP), 1988.

Abstract

The primary structure of a pyrimidine base-specific ribonuclease from bovine brain was determined. The sequence determined is (sequence; see text). Although the sequence homology of this RNase with bovine pancreatic RNase A is 78.2%, it consists of 140 amino acid residues, and it is 16 amino acid residues longer than RNase A at the carboxyl-terminal. In addition to an N-glycosylated long carbohydrate chain, the bovine brain RNase has two short O-glycosylated carbohydrate chains at the 129th and the 133rd serine residues. The additional C-terminal tail of the bovine brain RNase has a unique composition: 6 proline, 5 hydrophobic amino acids, and two basic amino acids, arginine and histidine.

Details

ISSN :
17562651 and 0021924X
Volume :
104
Database :
OpenAIRE
Journal :
The Journal of Biochemistry
Accession number :
edsair.doi...........da69b759a86293f9239a4116083e4f27