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Rhodium-Catalyzed Dehydrogenative Annulation of N-Arylmethanimines with Vinylene Carbonate for Synthesizing Quinolines

Authors :
Jiacheng Yin
Jiang Nan
Xin Ren
Yangmin Ma
Yan Hu
Guanjie Huang
Source :
Organic Letters. 23:8527-8532
Publication Year :
2021
Publisher :
American Chemical Society (ACS), 2021.

Abstract

Here we report a novel Rh-catalyzed C-H/C-H alkenylation of N-arylmethanimines with vinylene carbonate acting as a vinylene unit. Forty examples of C3,C4-nonsubstituted quinolines were achieved from commercially available starting materials. This identified process features an exceedingly simple system, a lower loading of catalyst, and the capacity for postfunctionalization with bioactive molecules.

Details

ISSN :
15237052 and 15237060
Volume :
23
Database :
OpenAIRE
Journal :
Organic Letters
Accession number :
edsair.doi...........da0fda912bd2526eb9e31c5108fd628d
Full Text :
https://doi.org/10.1021/acs.orglett.1c03231