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Novel and Convenient Approach to Synthesis of AZT/d4T H-phosphonates

Authors :
Hua Fu
Guang-Zhong Tu
Yufen Zhao
Changxue Lin
Source :
Chinese Journal of Chemistry. 22:225-227
Publication Year :
2010
Publisher :
Wiley, 2010.

Abstract

A convenient, efficient and general method has been developed for synthesis of H-phosphonate mono and diesters of AZT and d4T through one-pot reaction of phosphonic acid with AZT or d4T and different alcohols using pivaloyl chloride as condensing agent under mild conditions.

Details

ISSN :
1001604X
Volume :
22
Database :
OpenAIRE
Journal :
Chinese Journal of Chemistry
Accession number :
edsair.doi...........d9f3ac5e9fa48a9d4312205069f2b1d8