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55 RISK FACTORS ASSOCIATED WITH RELAPSES IN PEDIATRIC LUMINAL CROHN'S DISEASE, A RETROSPECTIVE COHORT STUDY

Authors :
Samuel Sassine
Lisa Djani
Christine Cambron-Asselin
Mathieu Savoie-Robichaud
Yi Fan Lin
Marwa Qaddouri
Souhila Fadela Zekhnine
Kelly Grzywacz
Véronique Groleau
Martha Dirks
Éric Drouin
Ugur Halac
Valérie Marchand
Chloé Girard
Olivier Courbette
Natalie Patey
Dorothée Dal Soglio
Colette Deslandres
Prévost Jantchou
Source :
Paediatrics & Child Health. 27:e26-e27
Publication Year :
2022
Publisher :
Oxford University Press (OUP), 2022.

Abstract

Background Crohn's diseaseis an inflammatory bowel disease that has a high incidence in Northern countries. The relapse rate of Crohn's disease one year after diagnosis is around 40 to 50% for all treatment modalities combined. Few risk factors are associated with the risk of relapses of Crohn's disease in children. Objectives The aims of this retrospective cohort study were to describe the rate of relapses in children with Crohn's disease, its evolution over the past decade and to determine risk factors associated with relapse. Design/Methods Patients under 18 years old and diagnosed between 2009 and 2019 were included. Patients’ clinical, endoscopic, histological, and laboratory characteristics, as well as their treatments, were collected from their medical records and the prospective CHU Sainte-Justine inflammatory bowel disease registry. Survival analyses and Cox regression models were used to assess the impact of those risk factors on relapse. Results 639 patients were included. There was a decrease in the clinical relapse rate over the past decade: 70.9% of patients diagnosed between 2009 and 2014 experienced a relapse compared to 49.1% of patients diagnosed between 2015 and 2019 (p Conclusion Relapse risk was significantly associated with baseline clinical, endoscopic, histological and laboratory data and treatment strategies. These results could help better select treatment options for pediatric Crohn's disease at induction and maintenance. Figure 1: Kaplan-Meier curve representing patients time to relapse according to the first maintenance treatment administered. Figure 2: Kaplan-Meier curve representing patients time to relapse according to the mean infliximab level in post-induction.

Details

ISSN :
19181485 and 12057088
Volume :
27
Database :
OpenAIRE
Journal :
Paediatrics & Child Health
Accession number :
edsair.doi...........d9cf20fe67af9c3648c86d3bdef1b7b6
Full Text :
https://doi.org/10.1093/pch/pxac100.054