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GENETIC VARIANTS RELATED TO LIPID METABOLISM AS A RISK FACTOR TO LATE-ONSET ALZHEIMER’S DISEASE
- Source :
- Journal of Aging Research and Lifestyle. :1-5
- Publication Year :
- 2017
- Publisher :
- SERDI, 2017.
-
Abstract
- Background: Genetic polymorphisms in genes regulating cholesterol metabolism have been suggested to risk factor of developing Alzheimer’s disease (AD). Objective: to analyze the frequency of polymorphisms apolipoprotein E (APOE-HhaI) and adenosine triphosphate binding cassette transporter 1 (ABCA1-StyI) in patients with late-onset AD. Design: case-control study. Participants: We studied 166 subjects (≥65 years old): Study Group (SG)- 88 patients and Control Group (CG)- 88 without dementia. Setting: The polymorphisms were determined using the polymorphism chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods. It was applied Fisher's exact/chi-square tests (P
- Subjects :
- lipids (amino acids, peptides, and proteins)
Subjects
Details
- ISSN :
- 2534773X
- Database :
- OpenAIRE
- Journal :
- Journal of Aging Research and Lifestyle
- Accession number :
- edsair.doi...........d95bd4e9803be5ce990c19247a34b1f3