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Left Atrial Strain in the Repaired Tetralogy of Fallot Population: Comparisons to Biventricular Function, Native T1 Values, Exercise Parameters and Healthy Controls

Authors :
Andrew N. Redington
Vien T. Truong
Paul J. Critser
Tarek Alsaied
Joshua Germann
Hieu T. Ta
Wojciech Mazur
Sean Lang
Philip R. Khoury
Justin T. Tretter
Nicholas J Ollberding
Adam W. Powell
Source :
Pediatric Cardiology. 42:1102-1110
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

Non-invasive imaging markers in patients with repaired tetralogy of Fallot (rTOF) are still being investigated to inform clinical decision making. Atrial function is a prognostic indicator in many acquired and congenital heart diseases. We sought to examine the relationship between cardiac MRI (CMR)-derived indices of left atrial (LA) function, native left ventricular (LV) T1 values, biventricular systolic function, and exercise capacity in rTOF. Sixty-six patients with rTOF without prior pulmonary valve replacement who underwent CMR (median age 18.5 years) were identified. Twenty-one adult rTOF patients (age range 19–32 years) were compared with 20 age-matched healthy volunteers (age range 19–34 years). LA reservoir, conduit, and pump global longitudinal strain (GLS) and strain rate (SR) were determined by tissue tracking. Native LV T1 values were measured on rTOF patients. Pearson correlations were performed to determine bivariate associations. Adult rTOF patients had higher pump GLS, pump:conduit, and pump:reservoir GLS ratios, and lower conduit:reservoir GLS ratio, LV ejection fraction (EF), and right ventricular EF compared to controls (p

Details

ISSN :
14321971 and 01720643
Volume :
42
Database :
OpenAIRE
Journal :
Pediatric Cardiology
Accession number :
edsair.doi...........d93bb1aaa6a3c4b733cad3e076f156bc
Full Text :
https://doi.org/10.1007/s00246-021-02587-0