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The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly

Authors :
Pablo Lara-Gonzalez
Christian O. De Groot
Andrew K. Shiau
Arshad Desai
Jack Houston
Joost Monen
Adina Gerson-Gurwitz
Karen Oegema
Bethany Davis
Source :
Molecular Biology of the Cell. 32:1193-1201
Publication Year :
2021
Publisher :
American Society for Cell Biology (ASCB), 2021.

Abstract

Caenorhabditis elegans builds centromeres using the histone H3 variant CENP-A but lacks a CENP-A-specific chaperone. This article shows that the extended N-terminal tail of C. elegans CENP-A, which interacts with the conserved loading factor KNL-2 and is essential for loading, provides at least part of the function of the dedicated chaperone.

Details

ISSN :
19394586 and 10591524
Volume :
32
Database :
OpenAIRE
Journal :
Molecular Biology of the Cell
Accession number :
edsair.doi...........d92fa5f26e311c5361f3c09c5c80572d
Full Text :
https://doi.org/10.1091/mbc.e20-12-0798