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The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly
- Source :
- Molecular Biology of the Cell. 32:1193-1201
- Publication Year :
- 2021
- Publisher :
- American Society for Cell Biology (ASCB), 2021.
-
Abstract
- Caenorhabditis elegans builds centromeres using the histone H3 variant CENP-A but lacks a CENP-A-specific chaperone. This article shows that the extended N-terminal tail of C. elegans CENP-A, which interacts with the conserved loading factor KNL-2 and is essential for loading, provides at least part of the function of the dedicated chaperone.
Details
- ISSN :
- 19394586 and 10591524
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Molecular Biology of the Cell
- Accession number :
- edsair.doi...........d92fa5f26e311c5361f3c09c5c80572d
- Full Text :
- https://doi.org/10.1091/mbc.e20-12-0798