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Quantification of familial risk of nasopharyngeal carcinoma in a high-incidence area
- Source :
- Cancer. 123:2716-2725
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- BACKGROUND To the authors' knowledge, no studies to date have explored familial risks of nasopharyngeal carcinoma (NPC) in detail and quantified its lifetime risk in high-incidence populations. METHODS The authors conducted a population-based case-control study of 2499 NPC cases and 2576 controls randomly selected in southern China from 2010 through 2014. Unconditional logistic regression was used to estimate multivariable-adjusted odds ratios (ORs) with 95% confidence intervals (95% CIs) associated with a family history of NPC. In addition, the authors compiled a reconstructed cohort comprising 40,781 first-degree relatives of cases and controls to calculate the lifetime cumulative risk of NPC. RESULTS Individuals with a first-degree family history of NPC were found to be at a >4-fold risk of NPC (OR, 4.6; 95% CI, 3.5-6.1) compared with those without such a history, but had no excess risk of other malignancies. The excess risk was higher for a maternal than a paternal history and was slightly stronger for a sibling compared with a parental history, and for a sororal than a fraternal history. Among relatives of cases, the cumulative risk of NPC up to age 74 years was 3.7% (95% CI, 3.3%-4.2%), whereas that among relatives of controls was 0.9% (95% CI, 0.7%-1.2%). Cumulative risk was higher in siblings than in parents among relatives of cases, whereas no such difference was noted among relatives of controls. CONCLUSIONS Individuals with a family history of NPC have a substantially higher risk of NPC. These relative and cumulative risk estimates can guide the development of strategies for early detection and clinical consultation in populations with a high incidence of NPC. Cancer 2017;123:2716-25. © 2017 American Cancer Society.
- Subjects :
- 0301 basic medicine
Cancer Research
education.field_of_study
business.industry
Incidence (epidemiology)
Population
Nasopharyngeal neoplasm
Absolute risk reduction
Odds ratio
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Oncology
030220 oncology & carcinogenesis
otorhinolaryngologic diseases
Medicine
Family history
Risk assessment
education
business
Demography
Cohort study
Subjects
Details
- ISSN :
- 0008543X
- Volume :
- 123
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi...........d901df774693cfdd3dd697063b4dc88c