Back to Search
Start Over
Nano Calcium Oxide Incorporated Hydrocolloid Dressings for Wound Care
- Source :
- Journal of Pharmaceutical Innovation. 17:215-226
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The study aimed to formulate hydrocolloid dressings incorporated with nano calcium oxide for effective wound healing. Hydrocolloid dressings create an insulated, moist environment in the wound bed for controlling the exudate and promoting autolytic debridement. Calcium ions play an important role in wound response and are considered to be an initial trigger in our immune response to healing, and research has shown that Ca2+ in the external medium is essential for wound repair. Seventy five parts per million of nano calcium oxide (NCO) obtained by thermal decomposition of calcium nitrate at 450 °C was used in the preparation of hydrocolloid dressings along with varying concentrations of micronized xanthan gum and HPMC. The dressings were evaluated for their surface characteristics, thickness, mechanical properties, folding endurance, pH, viscosity, swelling studies, water vapor transmission, and in vivo wound healing activity. The average particle size of NCO was found to be 307.8 nm. The SEM (scanning electron microscopy) analysis of the dressing revealed a porous surface and EDX (energy dispersive X-ray spectroscopy) characterization showed intense peaks of calcium and oxygen. The formulated dressings possessed uniform thickness, flexibility, and mechanical strength. The percentage of wound contraction was higher in wounds treated with formulated hydrocolloid dressings in comparison to standard commercial product (DuoDERM® hydrocolloid dressing) and control (untreated) group. The wound healing properties of hydrocolloid dressings were confirmed by histopathological analysis. Nano calcium incorporated hydrocolloid dressings with enhanced wound healing activity were developed successfully.
- Subjects :
- Hydrocolloid dressing
Materials science
integumentary system
Pharmaceutical Science
chemistry.chemical_element
02 engineering and technology
Calcium
equipment and supplies
021001 nanoscience & nanotechnology
030226 pharmacology & pharmacy
Calcium nitrate
Folding endurance
03 medical and health sciences
chemistry.chemical_compound
Wound care
0302 clinical medicine
chemistry
Drug Discovery
medicine
Swelling
medicine.symptom
0210 nano-technology
Calcium oxide
Wound healing
Biomedical engineering
Subjects
Details
- ISSN :
- 19398042 and 18725120
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmaceutical Innovation
- Accession number :
- edsair.doi...........d8ff4e921d79a60ba680f508a95b7f56