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Functional micelles formed from glucose-, thermo- and pH-triple responsive copolymers for controlled release
- Source :
- Polymer Chemistry. 8:4869-4877
- Publication Year :
- 2017
- Publisher :
- Royal Society of Chemistry (RSC), 2017.
-
Abstract
- A glucose-, thermo-, and pH-triple responsive copolymer, poly(2-phenylboronic esters-1,3-dioxane-5-ethyl) methylacrylate-b-poly(2-(N,N-dimethylamino)ethyl methacrylate) (PPBDEMA-b-PDMAEMA), was synthesized through atom transfer radical polymerization (ATRP). Benefiting from its amphiphilicity, PPBDEMA-b-PDMAEMA could self-assemble in water into micelles with the PPBDEMA core and the PDMAEMA shell. Glucose would react with PPBDEMA, leading to the expansion of the micelles. Because of the thermo-responsive PDMAEMA segment, increasing temperature would cause the PDMAEMA shell to shrink and the micelles to aggregate. Both PPBDEMA and PDMAEMA segments were found to have pH-responsive properties, but PDMAEMA responded faster than PPBDEMA upon pH stimulus. When the pH value was high (>8), the original copolymer micelles would disassemble and new micelles with the PPBDEMA shell and the PDMAEMA core would form after 48 h. PPBDEMA-b-PDMAEMA copolymer micelles could be used as smart carriers to achieve the multi-controlled release of insulin and Nile red fluorescent dye molecules by adjusting the temperature, the pH value, and the glucose concentration. The release rate of insulin from the micelles at high glucose concentrations was much faster than that at lower glucose concentrations at the physiological pH value and could be further accelerated by heating. Meanwhile, increasing the temperature, the pH value, and the glucose concentration would increase the release rate of Nile red from the micelles.
- Subjects :
- Polymers and Plastics
Atom-transfer radical-polymerization
Chemistry
Organic Chemistry
Nile red
Bioengineering
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
Methacrylate
01 natural sciences
Biochemistry
Fluorescence
Micelle
Controlled release
0104 chemical sciences
chemistry.chemical_compound
Polymer chemistry
Copolymer
Molecule
0210 nano-technology
Subjects
Details
- ISSN :
- 17599962 and 17599954
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Polymer Chemistry
- Accession number :
- edsair.doi...........d8dbe60033cc7afdcebf14468ba6963b