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Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in Inflammatory Bowel Disease
- Source :
- Hypoxia. 8:1-12
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Background Inflammation results in significant shifts in tissue metabolism. Recent studies indicate that inflammation and hypoxia occur concomitantly. We examined whether circulating and tissue markers of hypoxia could serve as surrogate indicators of disease severity in adult and pediatric patients with inflammatory bowel disease (IBD). Methods Serum and colonic biopsies were obtained from pediatric subjects with active IBD colitis and adult subjects with active and inactive ulcerative colitis, along with healthy non-colitis controls of all ages. Disease activity was evaluated by endoscopy and histopathology. Levels of serum hypoxia markers (macrophage inflammatory protein-3α [MIP-3α], vascular endothelial growth factor [VEGF], and erythropoietin [EPO]) were measured. Results Children with active IBD colitis had higher levels of serum MIP-3α and VEGF compared to non-colitis controls (p
- Subjects :
- Crohn's disease
medicine.medical_specialty
business.industry
Inflammation
Hypoxia (medical)
medicine.disease
Inflammatory bowel disease
Gastroenterology
Ulcerative colitis
3. Good health
Vascular endothelial growth factor
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
chemistry
Internal medicine
medicine
Histopathology
030212 general & internal medicine
medicine.symptom
Colitis
business
Subjects
Details
- ISSN :
- 23241128
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Hypoxia
- Accession number :
- edsair.doi...........d85eed8dff8959a37bd76235a251820b