A monoadduct generating Ru(<scp>ii</scp>) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin

Authors :: Richard J. Mitchell
Sarah M. Kriger
Alexander D. Fenton
Dmytro Havrylyuk
Ankit Pandeya
Yang Sun
Tami Smith
Jason E. DeRouchey
Jason M. Unrine
Viral Oza
Jessica S. Blackburn
Yinan Wei
David K. Heidary
Edith C. Glazer
Source :: RSC Chemical Biology. 4:344-353
Publication Year :: 2023
Publisher :: Royal Society of Chemistry (RSC), 2023.
Abstract: Phenanthriplatin forms DNA mono-adducts and induces ribosome biogenesis stress. Using a semi-rational strategy, Ru(ii) complexes were created that act as biological mimics of phenanthriplatin with improved properties.

Subjects :: Chemistry (miscellaneous)
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Molecular Biology
Biochemistry

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