ChemInform Abstract: A Practical Synthetic Route to Benzofuro[2,3-b]pyridine and Trifluoromethyl-α-carbolines

In situ generated benzofuran-2-amine reacts with 1,3-CCC-dielectrophiles, such as CF 3 -containing β-diketones, 3-formylchromone, methyl-2,4-dioxopentanoate and pentafluoro-benzaldehyde, and the reaction leads to the formation of benzofuro[2,3- B]pyridine ring system. By using a similar approach 4-trifluoromethyl-α-carbolines were synthesized starting from indole-2-amine.