Oxidative Stress As an Indicator of Metabolic Impairments in the Pathogenesis of Cerebral Stroke

Objective. To verify oxidative stress as an indicator of metabolic impairments in the complex cascade of the pathogenesis of hemorrhagic (HS) and ischemic (IS) stroke. Materials and methods. A total of 50 patients with HS and 50 with IS, along with 20 healthy subjects, were studied. All patients underwent complex biochemical blood tests, assessment of free radical oxidation (ketodienes, diene conjugates, malondialdehyde, dityrosine, and Schiff bases), and evaluation of the endogenous antioxidant defense system (vitamin E, reduced glutathione, total antioxidant activity, superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase) – a total of 12 indicators. Results. In patients with IS and HS, in contrast to the control group, complex biochemical investigations revealed an increase in the intensity of free radical oxidation of lipids and proteins, along with a functional imbalance in the nonenzymatic and enzymatic branches of the endogenous antioxidant defense systems. Conclusions. These results identify two factors in the formation of oxidative stress in IS and HS, widening our knowledge of the pathogenesis of this severe vascular process.