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Antithymocyte globulin for aplastic anemia secondary to pembrolizumab: a case report and review of literature
- Source :
- Immunotherapy. 15:323-333
- Publication Year :
- 2023
- Publisher :
- Future Medicine Ltd, 2023.
-
Abstract
- Aplastic anemia is a rare but potentially serious complication of immune checkpoint inhibitor therapy. The authors present a case of pembrolizumab-induced aplastic anemia that was refractory to steroids but had some hematologic response to modified-dosing antithymocyte globulin (ATG). This is the first reported case of hematological response to ATG for immune checkpoint inhibitor-induced aplastic anemia and the first reported case of modified ATG dosing for this indication. Cases of immune checkpoint inhibitor-induced aplastic anemia and management options are also summarized. Given the high morbidity and mortality associated with ICI-induced aplastic anemia, more data is necessary to guide evidence-based management recommendations.
- Subjects :
- Oncology
Immunology
Immunology and Allergy
Subjects
Details
- ISSN :
- 17507448 and 1750743X
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Immunotherapy
- Accession number :
- edsair.doi...........d7326d42b1f12e215d08df6ec10ed6a3