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Effects of Antitumor Drug Sorafenib on Chick Embryo Development
- Source :
- The Anatomical Record. 298:1271-1281
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Sorafenib has been used as an oral anti-cancer drug because of its ability to inhibit tumor growth. However, the pharmacological effect of sorafenib is still the lack of in vivo experimental evidence. Tumor and embryonic cells share some similar features, so we investigated the effects of sorafenib on the development of gastrulating chick embryos. We found that sorafenib exposure was markedly attributed to the number of embryonic cell in proliferation and apoptosis. We also detected sorafenib significantly interfered with epithelial-mesenchymal transition (EMT). Furthermore, sorafenib treatment impaired the production and migration of neural crest cells.
- Subjects :
- Drug
Sorafenib
medicine.medical_specialty
Histology
media_common.quotation_subject
Biology
urologic and male genital diseases
In vivo
Internal medicine
medicine
heterocyclic compounds
neoplasms
Ecology, Evolution, Behavior and Systematics
media_common
Embryogenesis
Neural crest
Embryonic stem cell
female genital diseases and pregnancy complications
digestive system diseases
Gastrulation
Endocrinology
Apoptosis
Cancer research
Anatomy
Biotechnology
medicine.drug
Subjects
Details
- ISSN :
- 19328486
- Volume :
- 298
- Database :
- OpenAIRE
- Journal :
- The Anatomical Record
- Accession number :
- edsair.doi...........d72d6e06fd20f4e0088b323e7d4464bd