A phase I/II clinical trial of veliparib (ABT-888) and radiation followed by maintenance therapy with veliparib and temozolomide in patients with newly diagnosed diffuse intrinsic pontine glioma (DIPG): A Pediatric Brain Tumor Consortium Interim Report of Phase I Study

Authors :: Arnold C. Paulino
Patrick A. Thompson
James M. Boyett
Evelyn McKeegan
Maryam Fouladi
Susan M. Blaney
Xia Wan
Tina Young-Poussaint
Edward R. Smith
Patricia Baxter
Vincent L. Giranda
Xiao-Nan Li
Arzu Onar-Thomas
Catherine A. Billups
Sridharan Gururangan
Jack Su
Stewart Goldman
Source :: Journal of Clinical Oncology. 33:10053-10053
Publication Year :: 2015
Publisher :: American Society of Clinical Oncology (ASCO), 2015.
Abstract: 10053 Background: We report the results of the dose escalation component of a phase 1/2 trial in children with newly diagnosed DIPG designed to determine the maximum tolerated dose (MTD) and toxici...

Subjects :: Oncology
Cancer Research
medicine.medical_specialty
Temozolomide
Pediatric Brain Tumor Consortium
Veliparib
business.industry
Newly diagnosed
Phase i study
Clinical trial
chemistry.chemical_compound
Maintenance therapy
chemistry
Internal medicine
medicine
In patient
business
Nuclear medicine
medicine.drug

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