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The microbiota of the bilio-pancreatic system: a cohort, STROBE-compliant study
- Source :
- Infection and Drug Resistance. 12:1513-1527
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Background: The gut microbiota play an essential role in protecting the host against pathogenic microorganisms by modulating immunity and regulating metabolic processes. In response to environmental factors, microbes can hugely alter their metabolism. These factors can substantially impact the host and have potential pathologic implications. Particularly pathogenic microorganisms colonizing pancreas and biliary tract tissues may be involved in chronic inflammation and cancer evolution. Purpose: To evaluate the effect of bile microbiota on survival in patients with pancreas and biliary tract disease (PBD). Patients and Methods: We investigated 152 Italian patients with cholelithiasis (CHL), cholangitis (CHA), cholangiocarcinoma (CCA), gallbladder carcinoma (GBC), pancreas head carcinoma (PHC), ampullary carcinoma (ACA), and chronic pancreatitis (CHP). Demographics, bile cultures, therapy, and survival rates were analyzed in cohorts (T1 death
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
030106 microbiology
Gut flora
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Immunity
Internal medicine
Carcinoma
Medicine
Pharmacology (medical)
030212 general & internal medicine
Pharmacology
biology
business.industry
Gallbladder
Cancer
medicine.disease
biology.organism_classification
Infectious Diseases
medicine.anatomical_structure
Biliary tract
Pancreatitis
business
Pancreas
Subjects
Details
- ISSN :
- 11786973
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Infection and Drug Resistance
- Accession number :
- edsair.doi...........d6845ab89c857c986a4a43e54791933b